Targeting Insulin Receptor with a Novel Internalizing Aptamer
نویسندگان
چکیده
منابع مشابه
Targeting Insulin Receptor with a Novel Internalizing Aptamer
Nucleic acid-based aptamers are emerging as therapeutic antagonists of disease-associated proteins such as receptor tyrosine kinases. They are selected by an in vitro combinatorial chemistry approach, named Systematic Evolution of Ligands by Exponential enrichment (SELEX), and thanks to their small size and unique chemical characteristics, they possess several advantages over antibodies as diag...
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The aptamer is an oligonucleotide which is a short version of biological nucleic acids (such as DNA and RNA) with defined sequence of nucleotides. Based on the complexity of molecule, the aptamers lies in-between protein molecules and small chemical molecules. Aptamers have high specificity and affinity towards target proteins. They are screened from random sequences of oligonucleotides based o...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2016
ISSN: 2162-2531
DOI: 10.1038/mtna.2016.73